PrimeÂ® is the complete and concentrated conditioner for both fresh and saltwater. PrimeÂ® removes chlorine, chloramine and detoxifies ammonia. PrimeÂ® converts ammonia into a safe, non-toxic form that is readily removed by the tankâ€™s biofilter. PrimeÂ® may be used during tank cycling to alleviate ammonia/nitrite toxicity. PrimeÂ® detoxifies nitrite and nitrate, allowing the biofilter to more efficiently remove them. It will also detoxify any heavy metals found in the tap water at typical concentration levels. PrimeÂ® is non-acidic and will not impact pH. PrimeÂ® will not overactivate skimmers. Use at start-up and whenever adding or replacing water.